Using acamprosate and naltrexone together

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Using acamprosate and naltrexone together

Posted Mar 01, 2016 by Admin

Previous research shows that acamprosate increases the number of individuals who remain abstinent after alcohol detoxification. Research also shows that naltrexone may reduce relapse and desire to drink in social settings.Combined therapy: what does acamprosate and naltrexone combination tell us? Alcohol and Alcoholism. 2004; 39(6 542-547. http alcalc. oxfordjournals.org/cgi/content/full/). Naltrexone and acamprosate may both work to effectively reduce craving and relapse in alcohol treatment through different pharmacological pathways. Since both drugs are well-tolerated and show no evidence of dangerous interaction, researchers at the University Hospital of Hamburg in Germany examined the safety of combined.

The most significant side effects were diarrhea and nausea. The clinical studies suggested that combined treatment is more effective than acamprosate treatment alone as well as placebo. Reviewed clinical studies show that the synergistic effect of combined treatment lasts after 12 weeks of follow-up.This review suggests that the combination of acamprosate and naltrexone in alcohol treatment is efficacious and safe. Individuals who do not respond well to either acamprosate or naltrexone may benefit from combined treatment.

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Studies to date suggest higher efficacy of combined treatment with acamprosate and naltrexone compared to monotherapy, regarding prevention of relapse into heavy drinking and maintenance of abstinence, the authors conclude. This added benefit could be explained by subgroups of drug-specific responders, by synergistic effects within.The use of Naltrexone and/or acamprosate can be helpful during alcohol treatment, however, to achieve the greatest success, individuals would benefit from incorporating psychological intervention. Evidence-based addiction treatment incorporates cognitive behavior therapy (CBT) which enables individuals to learn ways to cope with cravings and eventually.

It should be noted that while these medications may ease withdrawal symptoms and reduce the risk of relapse, psychological intervention is often necessary for successful maintenance of alcohol recovery. Kiefer F, Wiedemann K.Given the large proportion of alcohol dependent subjects responding insufficiently to monotherapy with either acamprosate or naltrexone with the consequence of early relapse after detoxification, many patients might benefit from enhancing the efficacy of relapse-prevention treatment by combining acamprosate and naltrexone.