Pharmacokinetics and dialysability of naltrexone

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Pharmacokinetics and dialysability of naltrexone

Posted Mar 07, 2016 by Admin

The following regimen of naltrexone, given in conjunction with clonidine to attenuate withdrawal manifestations, has been studied. 38 50 mg once daily, following verification that the patient is free of opiates. 1 (See General under Dosage and Administration.) Optimum duration of therapy not established; 237 safety and efficacy established only in short-term (up to 12 weeks) studies. mg every 4 weeks or once a month following verification that the patient is free of opiates.

Single doses 50 mg may increase risk of hepatic injury; weigh possible risks against probable benefits of flexible dosing. 1 Ingestion of the naltrexone dose generally should be observed in a clinic setting or by a responsible family member to ensure compliance, in which case.

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247 Possible dose-related hepatocellular injury, manifested as increases in serum hepatic enzyme concentrations. (See Boxed Warning.) Manufacturers state that naltrexone-induced hepatocellular injury appears to be a direct toxic rather than an idiosyncratic effect.

102 (See General under Dosage and Administration.) Alternatively, some clinicians have administered 12.5 mg initially, followed by incremental increases of 12.5 mg daily until the usual dosage of 50 mg daily has been achieved.