Naltrexone (trexan) and acamprosate (campral)

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  • Which is better naltrexone and campral
    Posted May 01, 2016 by Admin

    In-Depth From A.D.A.M. Medications. In the U.S., three drugs are specifically approved to treat alcohol dependence: Naltrexone (ReVia, Vivitrol) Acamprosate (Campral).

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Naltrexone (trexan) and acamprosate (campral)

Posted Apr 23, 2016 by Admin

Medications for treating alcohol dependence From American Family Physician, by Steven H. Williams Medications for treating alcohol dependence primarily have been adjunctive interventions, and only three medications-disulfiram, naltrexone, and acamprosate-are approved for this indication by the U.S. These methodologic limitations and mixed results make it difficult to state clearly how many patients benefit from disulfiram. Disulfiram usually is given in a dosage of 250 mg per day with a maximum dosage of 500 mg per day.

In a study (13) involving psychiatric patients with major depression and alcohol dependence, those treated with 20 to 40 mg per day of fluoxetine over 12 weeks had fewer drinks, fewer drinking days, and fewer heavy drinking days than those receiving placebo.

How does Naltrexone (Trexan/Revia) Naltrexone (Revia/Nodict/Trexan) Baclofen (Lioresal) Acamprosate (Campral) Additional Information.

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(10) Acamprosate is available in 333-mg enteric, coated tablets; dosing is by weight (Table 1 (3,4). It is well tolerated with limited side effects, most commonly transient diarrhea (occurring in approximately 10 percent of patients).

Although there is good evidence supporting short-term benefit with naltrexone, the evidence for longer-term use is less compelling. The recommended dosage of naltrexone is 50 mg per day in a single dose.

Long-term opioid therapy for chronic pain or heroin dependence is a contraindication for naltrexone because the drug could precipitate severe withdrawal syndrome. Naltrexone has been shown to have dose-related hepatotoxicity, although generally this occurs at doses higher than those recommended for treatment of alcohol dependence.

A systematic review (10) of 15 studies showed that acamprosate reduces short-term and long-term (more than six months) relapse rates in patients with alcohol dependence when combined with psychosocial treatments. Outcomes in favor of acamprosate included fewer patients returning to drinking (68 versus 80 percent.