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Comparing naltrexone versus placebo or no pharmacological treatments, no statistically significant difference were noted for all the primary outcomes considered. The only outcome statistically significant in favour of naltrexone is re incarceration, RR 0.47 (95CI but results come only from two studies.
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Gov't, P.H.S. MeSH Terms 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology Animals Benzazepines/pharmacology Dopamine Agonists/pharmacology Dopamine Antagonists/pharmacology. Dose-Response Relationship, Drug Eating/drug effects Ergolines/pharmacology Food Deprivation/physiology. Haloperidol/pharmacology Male Naltrexone/pharmacology Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D1/drug effects. Receptors, Dopamine D2/drug effects Substances Benzazepines Dopamine Agonists. Pairing naltrexone with SKF-38393 produced reductions of deprivation-induced intake comparable to that of naltrexone alone. Keywords Food deprivation; Naltrexone; SKF-38393; SCH-23390; Quinpirole; Haloperidol; Opioids; D1 Receptor; D2 Receptor Copyright 1994 Published by Elsevier Inc.
Dopamine Antagonists Ergolines Receptors, Dopamine D1 Receptors, Dopamine D2. Quinpirole Naltrexone 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Haloperidol Grant Support DA04194/DA/NIDA NIH HHS/United States DA07135/DA/NIDA NIH HHS/United States LinkOut - more resources).
Both SKF-38393 (5-10 mg/kg) and SCH-23390 (100-200 micrograms/kg) significantly and dose dependently reduced deprivation-induced intake. Whereas quinpirole ( mg/kg) failed to alter deprivation-induced intake, haloperidol increased deprivation-induced intake at low (50 micrograms) doses and decreased intake at higher (100-500 micrograms/kg) doses.
Abstract Send to: See comment in PubMed Commons below. Pharmacol Biochem Behav. 1994 Sep;49(1 197-204. Hobbs DJ 1, Koch JE, Bodnar RJ. Author information 1Department of Psychology, Queens College, CUNY, Flushing 11367.