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Naltrexone dopamine agonist

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Gov't, P.H.S. MeSH Terms 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology Animals Benzazepines/pharmacology Dopamine Agonists/pharmacology Dopamine Antagonists/pharmacology. Dose-Response Relationship, Drug Eating/drug effects Ergolines/pharmacology Food Deprivation/physiology. Haloperidol/pharmacology Male Naltrexone/pharmacology Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D1/drug effects. Receptors, Dopamine D2/drug effects Substances Benzazepines Dopamine Agonists. Pairing naltrexone with SKF-38393 produced reductions of deprivation-induced intake comparable to that of naltrexone alone. Keywords Food deprivation; Naltrexone; SKF-38393; SCH-23390; Quinpirole; Haloperidol; Opioids; D1 Receptor; D2 Receptor Copyright 1994 Published by Elsevier Inc.

Dopamine Antagonists Ergolines Receptors, Dopamine D1 Receptors, Dopamine D2. Quinpirole Naltrexone 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Haloperidol Grant Support DA04194/DA/NIDA NIH HHS/United States DA07135/DA/NIDA NIH HHS/United States LinkOut - more resources).

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Both SKF-38393 (5-10 mg/kg) and SCH-23390 (100-200 micrograms/kg) significantly and dose dependently reduced deprivation-induced intake. Whereas quinpirole ( mg/kg) failed to alter deprivation-induced intake, haloperidol increased deprivation-induced intake at low (50 micrograms) doses and decreased intake at higher (100-500 micrograms/kg) doses.

Abstract Send to: See comment in PubMed Commons below. Pharmacol Biochem Behav. 1994 Sep;49(1 197-204. Hobbs DJ 1, Koch JE, Bodnar RJ. Author information 1Department of Psychology, Queens College, CUNY, Flushing 11367.