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Humans naltrexone

Posted Apr 30, 2016 by Admin

Abstract Send to: See comment in PubMed Commons below. J Pharm Biomed Anal. 1996 Sep;14(12 1717-25. Davidson AF 1, Emm TA, Pieniaszek HJ Jr. Author information 1Drug Metabolism and Pharmacokinetics Section, DuPont Merck Pharmaceutical Company, Stine-Haskell Research Center, Newark, DE 19714, USA. Abstract A sensitive and specific high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of naltrexone and its major metabolite, 6-beta-naltrexol, in human plasma. After alkalinizing 2 ml plasma samples with pH 9 sodium carbonate buffer, naltrexone and 6-beta-naltrexol were extracted.

A portion of the acid extract was chromatographed on a YMC phenyl column using a mobile phase of methanol-phosphoric acid (50 mM) (20:80, v/v) (pH 3.2) at a flow-rate of 1.2 ml min 1.

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PMID : 8887719 PubMed - indexed for MEDLINE. MeSH Terms, Substances MeSH Terms Chromatography, Liquid/methods Electrochemistry/methods. Humans Naltrexone/analogs derivatives Naltrexone/blood Narcotic Antagonists/blood Reproducibility of Results. Sensitivity and Specificity Substances Narcotic Antagonists 6 beta-hydroxynaltrexone Naltrexone.