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Exclusions: 10 people in the study; less than 2 weeks follow up; lack of relevant primary clinical data; or no quantitative results. Data were extracted on study scope and design, randomisation process, sample size, intervention, exclusion and inclusion criteria, baseline characteristics, length of treatment and.In all the acamprosate studies and in 15 of the naltrexone studies, all participants had been detoxified before treatment. Studies were predominantly conducted in ambulatory settings. Study duration ranged from three to 24 months. Previous Section. Next Section MAIN RESULTS. Thirty three studies met inclusion criteria. Thirteen studies compared acamprosate with placebo, 19 studies compared naltrexone with a control group (placebo or reference group and one study compared naltrexone with acamprosate.
Mar 8, 2013. Naltrexone and acamprosate are categorized as anticraving drugs. on the effects of combining naltrexone with acamprosate (Campral).This awaits confirmation. Previous Section Next Section References Kranzler HR, Van Kirk J. Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res 2001;25:133541. CrossRef Medline Web of Science Srisurapanont M, Jarusuraisin N.
Although studies mainly use strict selection criteria excluding other comorbidities and dependencies, a profile not seen in the usual clinic, Bouza et al confirm both agents work (although differently) in alcoholism treatment, are safe, and are acceptably tolerated.Acamprosate produced few side effects. The most common adverse events were gastrointestinal problems. In the short term, naltrexone significantly reduced relapse rate but not abstinence rate compared with controls (see table).
Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev 2002;2:CD001867 doi: 1858. Medline Mann K, Lehert P, Morgan MY. The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis.Two adjunctive medications, acamprosate and naltrexone, have been the subject of recent meta-analyses 1, 3 and reviews 4, 5 that support a beneficial therapeutic effect. Bouza et al s meta analysis includes 13 acamprosate studies (n 4000) and 19 naltrexone studies (n 3205).
How effective are disulfiram, naltrexone, and acamprosate for alcohol dependence?. In one comparison with data from four clinical trials, the combination of.Acamprosate improves adherence and abstinence rates, whereas naltrexone significantly reduces relapse rates, time to relapse, and frequency of drinking. However, the high level of non-compliance for both treatments may limit their usefulness.
Compliance figures varied widely (ranging from 40 to 90). Major areas of uncertainty include the need and type of psychosocial therapy best suited to each drug, the interaction between drug therapeutic profile/patient characteristics, and the optimal duration of treatment.Jan 8, 2014. Q Are acamprosate and naltrexone safe and effective treatments for. Comparing and combining naltrexone and acamprosate in relapse.
Comparing the course of nonrelapse rates between naltrexone and acamprosate, the naltrexone group showed a tendency for a better outcome regarding time to first drink and time to relapse. The combined medication was most effective with significantly lower relapse rates than placebo and acamprosate but.Addiction 2004;99:81128. CrossRef Medline Web of Science Q Are acamprosate and naltrexone safe and effective treatments for adults with alcohol dependence? Previous Section. Next Section METHODS Design: Systematic review with meta-analysis.